372 / 1708
A9961: Standard-Risk Medulloblastoma
2340 cGy CSI + posterior fossa boost
to total dose of 5580 cGy
Compared two different chemotherapy
Regimen: CCNU, CDDP, VCR vs.
CDDP, VCR, CPM
5-year EFS is 81%
No EFS or overall survival difference
Infection more common with CPM
Electrolyte abnormality more common
with CCNU
Packer RJ et al. J Clin Oncol 2006; 24:4202-8