942 / 1708
Clinical studies in localized Ewing’s sarcoma
St. Jude studies
UKCCSG/MRC studies
CESS studies
EICESS studies
Tumor size as prognostic factor (< or > 8 cm) (ES-
79), with less prognostic relevance when more
intensive treatment is used (EW-92)
Tumor site as the most important prognostic
factor (extremity vs axial vs pelvis) (ET-1)
Importance of high dose alkylating agents (ET-2)
Tumor volume (< or > 100 ml) and histological
response (CESS-81) as prognostic factors
Tumor volume (< or > 200 ml) and histologic
response as prognostic factors (CESS-86);
intensive treatment with Ifo for high risk pts
Type of local therapy, stage, histologic response