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The

European Intergroup Cooperative

Ewing’s Sarcoma Study

investigated

whether cyclophosphamide

has a similar efficacy as ifosfamide in

standard-risk (SR) patients and whether

the addition of etoposide improves

survival in high-risk (HR) patients.

-155 SR patients and 492 HR patients

were enrolled

- median follow-up 8.5 years