946 / 1708
SR-VACA arm SR-VAIA arm
3y EFS
73%
74%
3y OS
90%
86%
HR-EVAIA arm HR-VAIA arm
3y EFS
52%
47%
3y OS
62%
59%
In the
SR group
, the hazard ratios (VACA vs
VAIA) for EFS and OS were 0.91 (95% CI, 0.55 to
1.53) and 1.08 (95% CI, 0.58 to 2.03),
respectively. There was a higher incidence of
hematologic toxicities in the VACA arm.
In the
HR group
, the EFS and OS hazard ratios
(EVAIA v VAIA) indicated a 17% reduction in the
risk of an event (95% CI, 35% to 5%; P .12) and
15% reduction in dying (95% CI, 34% to 10%),
respectively.
Cyclophosphamide
seemed to have a similar effect on EFS and OS as ifosfamide in
SR patients but was associated with increased toxicity.
In HR patients, the addition of
etoposide
seemed to be beneficial