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TABLE 2. Univariate analysis of outcome predictors.
Overall
HPV negative
HPV positive
Variables
HR
95% CI
p
value
No. ofpatients
HR
95% CI
p
value
No. ofpatients
HR
95% CI
p
value
No. ofpatients
Age, y
1.027
1.006–1.05
.0129
295
1.023 0.997–1.050 .0871
117
1.011 0.974–1.050 .5602
171
Approach
Transoral
Ref
Ref
Ref
Open
2.732 1.822–4.096
<
.0001
296
1.449 0.865–2.426 .1589
117
3.899 1.964–7.742 .0001
172
Extranodal extension
No
Ref
Ref
Ref
Yes
2.364 1.582–3.532
<
.0001
286
2.396 1.432–4.010 .0009
111
1.921 0.985–3.744 .0553
169
HPV
Positive
Ref
Negative
3.393 2.255–5.106
<
.0001
289
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Marital status
Married
Ref
Ref
Ref
Single/divorced/widowed 1.625 1.064–2.481
.0247
275
1.671 0.963–2.898 .0680
104
1.203 0.595–2.433 .6067
164
Mucosal margins
Free of carcinoma
Ref
Ref
Ref
Positive
1.591 1.005–2.517
.0473
293
1.317 0.727–2.387 .3640
116
1.775 0.828–3.806 .1401
170
N classification
N0/N1
Ref
Ref
Ref
N2/N3
1.059 0.701–1.600
.7849
294
1.385 0.836–2.294 .2064
117
1.057 0.508–2.200 .8817
171
p16 status
Positive
Ref
Negative
2.983 1.999–4.453
<
.0001
288
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Perineural invasion
No
Ref
Ref
Ref
Yes
2.453 1.653–3.642
<
.0001
291
1.806 1.102–2.958 .0190
116
1.884 0.920–3.858 .0831
168
Primary site
BOT
Ref
Ref
Ref
Other
2.417 1.233–4.739
.0102
2.836 1.323–6.080 .0074
0.561 0.072–4.403 .5828
Tonsil
0.963 0.605–1.533
.8739
295
1.798 0.987–3.274 .0550
117
0.584 0.279–1.221 .1529
171
Race
White
Ref
African American/black
2.556 1.238–5.278
.0112
293
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
HPV risk group
Low
Ref
Intermediate
1.818 0.962–3.438
.0659
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
High
4.801 2.831–8.141
<
.0001
276
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
p16 risk group
Low
Ref
Intermediate
2.322 1.397–3.861
.0012
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
High
4.284 2.590–7.086
<
.0001
275
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Sex
Female
Ref
Ref
Ref
Male
1.223 0.743–2.013
.4292
296
0.949 0.507–1.776 .8691
117
1.268 0.553–2.909 .5752
172
S URGICAL MANAGEMENT OF OROPHARYNGEAL SCC
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