254 / 881
Parameters for clinical outcome: Brain
Endpoint: Symptomatic necrosis vs Asymptomatic necrosis
S-NEC Probability
V
12
Gy
[
cc
]
T Korytko et al. 12 Gy gamma knife radiosurgical volume is a predictor for radiation
necrosis in non-AVM intracranial tumors. Int. J. Radiation Oncology Biol. Phys.,
Vol. 64, No. 2, pp. 419–424, 2006
•
129 patients with 198 separate not-AVM
•
Radiosurgery technique (gamma-knife)
•
Median prescribed max dose 34.6 Gy
(range 22 Gy – 50 Gy)
•
Logistic regression
V
12
Gy
[
cc
]
S-NEC
[%]
V12 Gy
p = 0.007
WBRT
p = 0.03
Occipital and temporal location
p = 0.0001
Male sex
p = 0.03