ATP Barcelona 2017

252 / 881

Clinical evaluation: comparison of toxicity data
from different protocols
• Biologically Effective Dose
 A parameter that is independent from the fractionation
 It doesn’t express a real delivered dose
β α
β α
/
/
2
1
1
2
+
+ =
d
d
D
D
1
β α
β α
/ 0
/
1
1 +
+ = d
D
BED
2






+ ⋅ =






+ = 1
/
1
/
1
1
1
1 β α β α
d dN d D BED
3
N: fraction number
d1: fraction number
α/β: alfa-beta ratio
for the given effect