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Parameters for clinical outcome: Urinary bladder
Problems in urinary bladder toxicity evaluation:
1) Heterogeneous evidences
2) Poor reliability
3) Problems in volume stability during treatment duration:
Definition of Vdose and Dvolume not reliable with a single CT scan
V1
V2
S1
S2
critical
dose level
critical
dose level
V1<V2
S1≈S2