122
Biophysical Society 58
th
Annual Meeting, San Francisco, California
10:15
am
–12:45
pm
, R
oom
132/133
Platform
Voltage-gated K Channels: Mostly BK and
Structure Function
Co-Chairs
Lawrence Salkoff, Washington University School of Medicine, St. Louis
Ramón Latorre, University of Valparaíso, Chile
2204-P
lat
10:15
am
LOCATION OF BK ION PERMEATION GATE REVEALED BY
CD
2+
-CYS COORDINATION IN THE BK INNER PORE REGION.
Yu Zhou
, Christopher Lingle
2205-P
lat
10:30
am
IDENTIFICATION OF A DISCRETE ALCOHOL-SENSING SITE
IN THE BK (SLO1) CHANNEL. Anna Bukiya, Justin Edwards,
Alex Dopico
2206-P
lat
10:45
am
BASELINE PROPERTIES OF SLO1 K
+
(BK) CHANNELS WITHOUT
THE GATING RING.
Yanyan Geng
, Gonzalo Budelli, Alice Butler,
Celia Santi, Juan Ferreira, Lawrence Salkoff, Karl L. Magleby
2207-P
lat
11:00
am
DIVALENT CATION-DEPENDENT MOTION OF THE BK
CHANNEL GATING-RING REPORTED BY STATE DEPENDENT
FRET.
Pablo Miranda
, Teresa Giraldez, Miguel Holmgren
2208-P
lat
11:15
am
SUBSTITUTIONS AT F380 IN S6 BY SMALL HYDROPHOBIC
AMINO ACIDS MAKES THE OPENING TRANSITION IN BK
CHANNELS RATE LIMITING.
Willy Carrasquel-Ursulaez
,
Gustavo F. Contreras, Romina Sepúlveda, Daniel Aguayo,
Fernando D. Gonzalez-Nilo, Carlos González, Ramón Latorre
2209-P
lat
11:30
am
DYNAMIC CA
2+
SENSITIVITY OF BK CHANNELS. Panpan Hou,
Feng Xiao, Ming Yuchi, Guohui Zhang, Ying Wu, Wei Wang,
Wenping Zeng, Mingyue Ding, Zhengxing Wu, Jianming Cui,
Jiuping Ding
2210-P
lat
11:45
am
NMR STRUCTURAL STUDY OF THE DOMAINS OF THE KCNH
CHANNELS AND ITS INSIGHT INTO CHANNEL GATING.
Congbao Kang
2211-P
lat
12:00
pm
STRUCTURAL BASIS OF LIPID-DRIVEN CONFORMATIONAL
CHANGES IN THE HYPERPOLARIZATION-ACTIVATED
POTASSIUM CHANNEL MVP.
Amelia M. Randich
, Ernesto Vargas,
Sherry S. Wanderling, Eduardo Perozo
10:45
am
–12:45
pm
, R
oom
303
Platform
Protein Design and Folding
Co-Chairs
Daniel Hoersch, University of California, San Francisco
Dorothy Beckett, University of Maryland, College Park
2212-P
lat
10:45
am
SMOOTH FUNCTIONAL TRANSITION ALONG A
MUTATIONAL PATHWAY WITH AN ABRUPT PROTEIN FOLD
SWITCH.
Christian Holzgräfe
, Stefan Wallin
2213-P
lat
11:00
am
HYDOPHOBIC GUIDED PROTEIN FOLDING.
Alberto Perez
,
Justin L. MacCallum, Ken A. Dill
2214-P
lat
11:15
am
EXACT PARTITION FUNCTION ZEROS OF THE WAKO-SAITô-
MUñOZ-EATON PROTEIN MODEL.
Julian Lee
2215-P
lat
11:30
am
ALLOSTERIC COUPLING VIA COMMUNICATION OF DISTAL
DISORDER-TO-ORDER TRANSITIONS.
Dorothy Beckett
,
Christopher Eginton, Sharrol Bachas, Herschel Wade
2216-P
lat
11:45
am
RESHAPING ANTIBODY DIVERSITY.
Damian C. Ekiert
,
Feng Wang, Ian A. Wilson, Peter G. Schultz, Vaughn V. Smider
2217-P
lat
12:00
pm
COMPUTING CONFORMATIONAL ENTROPY IN ANTIBODY
INTERFACES.
Pablo Gainza
, Kyle E. Roberts, Mark A. Hallen,
Bruce R. Donald
2218-P
lat
12:15
pm
CONTROLLING PROTEIN BINDING SPECIFICITY BY A
CONFORMATIONAL SHIFT.
Servaas Michielssens
, Jan Henning Peters,
David Ban, Supriya Pratihar, Stefan Becker, Thomas Michael Sabo,
Karin Giller, Lee Donghan, Christian Griesinger, Bert de Groot
2219-P
lat
12:30
pm
REPROGRAMMING AN ATP-DRIVEN BIOLOGICAL MACHINE
INTO A LIGHT-GATED PROTEIN NANOCAGE.
Daniel Hoersch
,
Soung-Hun Roh, Wah Chiu, Tanja Kortemme
10:45
am
–12:45
pm
, R
oom
304
Platform
DNA Structure and Dynamics
Co-Chairs
Carey Phelps, University of Oregon
Steve Meisburger, Cornell University
2220-P
lat
10:45
am
SORTING OUT THE STRUCTURE OF SINGLE-STRANDED
DNA.
Steve Meisburger
, Julie Sutton, Huimin Chen, Kurt Andresen,
Lois Pollack
2221-P
lat
11:00
am
SINGLE MOLECULE FRET STUDIES OF DNA HAIRPIN FOLDING.
Katherine Truex
, Hoi Sung Chung, William A. Eaton, John Louis
2222-P
lat
11:15
am
FRICTION AND INTERACTIONS BETWEEN BARE DNA
MOLECULES: THE ROLE OF DNA HANDEDNESS.
Graeme A. King
, Ruggero Cortini, Dominic J. Lee, Alexei A. Kornyshev,
Gijs J.L Wuite
2223-P
lat
11:30
am
PHYSICAL MODELING OF CHROMOSOME SEGREGATION IN
E. COLI REVEALS IMPACT OF FORCE AND DNA RELAXATION.
Thomas J. Lampo
, Nathan J. Kuwada, Paul A. Wiggins,
Andrew J. Spakowitz
2224-P
lat
11:45
am
MULTIPLE DYNAMIC DNA REARRANGEMENTS ARE TIGHTLY
COUPLED TO DISTINCT STAGES OF HUMAN TELOMERASE
CATALYSIS.
Joseph Parks
2225-P
lat
12:00
pm
STUDIES OF T4 PRIMOSOME DNA UNWINDING BY SINGLE-
MOLECULE FLUORESCENCE-DETECTED LINEAR
DICHROISM.
Carey Phelps
