120
Biophysical Society 58
th
Annual Meeting, San Francisco, California
2172-P
lat
9:15
am
education
travel
awardee
ARCHITECTURAL ROLE OF HMO1 IN BENDING, BRIDGING
AND COMPACTING DNA.
Divakaran Murugesapillai
,
Micah J. McCauley, Ran Huo, Molly H. Nelson Holte,
L. James Maher III, Nathan E. Israeloff, Mark C. Williams
2173-P
lat
9:30
am
DIRECT VISUALIZATION OF DNA DYNAMICS DURING THE
TELOMERASE CATALYTIC CYCLE REVEALS THE FUNCTION
OF A CONSERVED TELOMERASE DOMAIN.
Benjamin M. Akiyama
, Michael D. Stone
2174-P
lat
9:45
am
TARGETING AND DEGRADATION OF VIRAL DNA BY THE
CRISPR-CAS SYSTEM OF ESCHERICHIA COLI.
Sy Redding
,
Samuel H. Sternberg, Prashant Bhat, Chantal K. Guegler,
Megan L. Hochstrasser, Blake Wiedenheft, Jennifer A. Doudna,
Eric C. Greene
2175-P
lat
10:00
am
SELECTIVE ACETYLATION REVEALS DISTINCT ROLES OF
HISTONES H3 AND H4 IN NUCLEOSOME DYNAMICS - A FRET
STUDY.
Alexander Gansen
, KatalinToth, Lars Nordenskiöld, Jörg Langowski
8:15
am
–10:15
am
, R
oom
305
Platform
Calcium Fluxes, Sparks, and Waves
Co-Chairs
Niall Macquaide, University of Glasgow, United Kingdom
Dmitry Terentyev, Brown University and Rhode Island Hospital
2176-P
lat
8:15
am
DECOMPOSITION OF A CALCIUM SPARK IN CARDIAC
MYOCYTES.
Didier X.P. Brochet
, W. Jonathan Lederer
2177-P
lat
8:30
am
EXAMINATION OF SINGLE CHANNEL RYR BEHAVIOR FROM
LONG-LASTING CA
2+
SPARKS. Cherrie HT KONG,
Mark B. Cannell
2178-P
lat
8:45
am
ACTIVITY OF BOTH PKA AND CAMKII IS REQUIRED FOR
MAXIMAL RYR SENSITIVITY UNDER BETA-ADRENERGIC
STIMULATION. Ardo Illaste,
Eva Polakova
, Ernst Niggli, Eric A. Sobie
2179-P
lat
9:00
am
CRITICAL REQUIREMENTS FORTHE INITIATIONOF A CARDIAC
ARRHYTHMIA IN HEART: CELL NUMBER. Aman Ullah,
Minh Tuan Hoang Trong, George S. B. Williams, Raimond L. Winslow,
William J. Lederer,
Mohsin S. Jafri
2180-P
lat
9:15
am
STRUCTURAL AND FUNCTIONAL ALTERATION OF RYR
CLUSTERS AFTER REMODELING IN PERSISTENT ATRIAL
FIBRILLATION.
Niall Macquaide
, Hoang-Trong M. Tuan,
Jun-Ichi Hotta, Wouter Sempels, Ilse Lenaerts, Patricia Holemans,
Johan Hofkens, Saleet Jafri, Rik Willems, Karin R. Sipido
2181-P
lat
9:30
am
SUBCELLULAR ORIGIN AND TISSUE-WIDE
SYNCHRONIZATION OF ABNORMAL CA RELEASE IN THE
GENESIS OF CA-DEPENDENT ATRIAL ARRHYTHMIA.
Qing Lou
, Bin Liu, Andriy E. Belevych, Przemyslaw Radwanski,
Anu Kalyanasundaram, Wolfgang H. Dillmann, Antonis A. Armoundas,
Bjorn C. Knollmann, Vadim V. Fedorov, Sándor Györke
2182-P
lat
9:45
am
HYPERPHOSPHORYLATION OF RYRS UNDERLIES TRIGGERED
ACTIVITY INTRANSGENIC RABBITMODEL OF LQT2 SYNDROME.
Dmitry Terentyev
, Weyian Li, Radmila Terentyeva, Leroy L. Cooper,
YiChun Lu, Hitesh Jindal, Xuwen Peng, Gideon Koren
2183-P
lat
10:00
am
RAPID CALCIUM MODULATION IN CELLS: DIRECT
INTRACELLULAR ACCESS USING NANOSTRAWS.
Alexander Xu
,
Sally A. Kim, Amin Aalipour, Nicholas A. Melosh
8:15
am
–10:15
am
, R
oom
306
Platform
Ion Channels and Disease
Co-Chairs
Heike Wulff, University of California, Davis
Melissa Miller, University of California, Berkeley
2184-P
lat
8:15
am
education
travel
awardee
A ROBUST HIGH-THROUGHPUT ASSAY FORTHERMODYNAMIC
CORRECTORS OF THE PREDOMINANT MOLECULAR DEFECT
CAUSING CYSTIC FIBROSIS.
Chi Wang
, Pradeep Kota,
Zhengrong Yang, Andrei Aleksandrov, Jianli An, Farhad Forouhar,
Greg Boel, Nikolay Dokholyan, John Riordan, Christie Brouillette, John Hunt
2185-P
lat
8:30
am
CONVERTING A STIMULATORY ATP BINDING SITE TO AN
INHIBITORY ONE BY THE DISEASE-ASSOCIATED MUTATION,
G551D.
Wen-Ying Lin
, Kang-Yang Jih, Tzyh-Chang Hwang
2186-P
lat
8:45
am
INFLUENZA A BLOCKERS WITH REDUCED RESISTANCE
FORMATION. Antonios Kolocouris, F. Brent Johnson, Roland Zell,
Michaela Schmidtke, Francesc X. Sureda, Timothy A. Cross, David Fedida,
Christina Tzitzoglaki, Harris Ioannidis, Anja Hoffman, Marta López-Querol,
Anna K. Wright, Daniel Kwan, Kelly McGuire,
David D. Busath
2187-P
lat
9:00
am
DUAL REGULATION OF G PROTEINS AND THE G
PROTEIN-ACTIVATED POTASSIUM CHANNELS (GIRK) BY
LITHIUM. Isabella Farhy Tselnicker, Vladimir Tsemakhovich, Ida Rishal,
Carmen W. Dessauer,
Nathan Dascal
2188-P
lat
9:15
am
THE MICROGLIAL K
+
CHANNELS KV1.3 AND KCA3.1 AS
POTENTIAL THERAPEUTIC TARGETS FOR ISCHEMIC STROKE.
Heike Wulff
, Yi-Je Chen, Paul D. Jenkins, Hai Nguyen, April L. Garing,
Ralf Köhler
2189-P
lat
9:30
am
EPILEPSY-ASSOCIATED POINT MUTATION IN THE PORE
DOMAIN OF KV2.1.
Kevin R. Bersell
, Benjamin S. Jorge,
Jennifer A. Kearney, Alfred L. George, Jr.
2190-P
lat
9:45
am
MOLECULAR DYNAMICS STUDIES OF ION PERMEATION
IN HUMAN VOLTAGE-GATED PROTON CHANNEL.
Kulleperuma Kulleperuma
, Deri Morgan, Borris Musset,
Susan M.E. Smith, Sindhu Rajan, Vladimir V. Cherny,
Thomas E. DeCoursey, Regis Pomes
2191-P
lat
10:00
am
REGULATION OF CATSPER CHANNEL THROUGH
NON-CONVENTIONAL LIPID SIGNALING.
Melissa R. Miller
,
Yuriy Kirichok, Polina Lishko
