123
Biophysical Society 58
th
Annual Meeting, San Francisco, California
T
U
E
S
D
A
Y
2226-P
lat
12:15
pm
OBSERVING TAUTOMERIZATION OF A DEOXYCYTIDINE
ANALOG KP1212: MOLECULAR ORIGIN OF LETHAL
MUTAGENESIS AGAINST HIV.
Chunte Sam Peng
, Carlos Baiz,
Mike Reppert, Deyu Li, Bogdan I. Fedeles, Vipender Singh,
John M. Essigmann, Andrei Tokmakoff
2227-P
lat
12:30
pm
DNA SEQUENCING WITH PROTEIN NANOPORES: A STORY
OF STRANDS AND NUCLEOTIDES.
Syma Khalid
, Andrew T. Guy,
Richard Manara, Jayne Wallace
10:45
am
–12:45
pm
, R
oom
305
Platform
Membrane-Active Peptides and Toxins
Co-Chairs
Burkhard Bechinger, University of Strasbourg/CNRS, France
Shirley Schreier, University of Sao Paulo, Brazil
2228-P
lat
10:45
am
LIPID-MEDIATED POLYPEPTIDE INTERACTIONS INMEMBRANES:
CASE STUDY ONTHE SYNERGISM BETWEEN LINEAR CATIONIC
ANTIMICROBIAL PEPTIDES. Evgeniy S. Salnikov, Elise Glattard,
Hiba Sarrouj, Arnaud Marquette, Christopher Aisenbrey, Olivier Ouari,
Paul Tordo, Frank Engelke, Fabien Aussenac,
Burkhard Bechinger
2229-P
lat
11:00
am
education
travel
awardee
MULTISCALE SIMULATIONS OF DIPHTHERIA TOXIN T-DO-
MAIN MEMBRANE ASSOCIATION.
Jose C. Flores-Canales
,
Alexey S. Ladokhin, Maria Kurnikova
2230-P
lat
11:15
am
PEPTIDE:LIPID RATIO AND MEMBRANE SURFACE CHARGE
MODULATE THE MECHANISM OF ACTION OF THE
ANTIMICROBIAL PEPTIDE BP100.
Shirley Schreier
,
Mariana C. Manzini, Katia R. Perez, Karin A. Riske, José C. Bozelli JR,
Mario J. Politi, Ana P. Valente, Fabio C. Almeida, Hernan Chaimovich,
Magali A. Rodrigues, Marcelo P. Bemquerer, Iolanda M. Cuccovia
2231-P
lat
11:30
am
THE USE OF SURFACE PLASMON-BASED INFRARED
SPECTROSCOPY TO DETECT INTERCELLULAR JUNCTIONS
ALTERATIONS IN INFLAMED INTESTINAL CELLS.
Amir Bein
,
Alexander Zilbershtein, Michael Golosovsky, Dan Davidov, Betty Schwartz
2232-P
lat
11:45
am
POINT MUTATION IN THE HYDROPHOBIC REGION DRIVES
SELECTIVITY AND ACTIVITY OF OP-145, A DERIVATIVE OF
HUMAN CATHELICIDIN LL-37.
Nermina Malanovic
,
Jan Wouter Drijfhout, Manfred Kriechbaum, Maria Schmuck,
Anna de Breij, Peter Nibbering, Karl Lohner
2233-P
lat
12:00
pm
LOCALIZED PERMEABILIZATION OF E. COLI MEMBRANES
BY THE ANTIMICROBIAL PEPTIDE CECROPIN A.
Nambirajan Rangarajan
, Somenath Bakshi, James Carl Weisshaar
2234-P
lat
12:15
pm
DEVELOPMENT OF FUNCTIONAL ARTIFICIAL ION CHANNELS
USING PEPTIDE NANOSTRUCTURES.
Normand Voyer
,
François Otis, Eric Biron, Charles Racine-Berthiaume, Michèle Auger,
Kyle Hartwick, Marise Ouellet
2235-P
lat
12:30
pm
SWITCHINGTHE ANTIMICROBIAL ACTIVITY OF GRAMICIDIN S
BY LIGHT.
Oleg Babii
, Segrii Afonin, Marina Berditsch, Sabine Reisser,
Thomas Steinbrecher, Pavel Mykhailiuk, Igor Komarov, Anne S. Ulrich
10:45
am
–12:45
pm
, R
oom
306
Platform
Microtubules and Motors
Co-Chairs
Jennifer Ross, University of Massachusetts, Amherst
William Hancock, Pennsylvania State University
2236-P
lat
10:45
am
3.8 ANGSTROM RESOLUTION STRUCTURE OF MICROTUBULE
BY CRYO-EM.
Rui Zhang
, Gregory Alushin, Elizabeth Kellogg, Eva Nogales
2237-P
lat
11:00
am
TUBULIN COFACTORS FORM A MULTI-PROTEIN PLATFORMS
THAT REGULATE THE SOLUBLE TUBULIN POOL AND
PROMOTE MICROTUBULE POLYMERIZATION.
Stanley Nithianantham, Sinh Le, Shu Ti, Elbert Seto,
Jawdat Al-Bassam
2238-P
lat
11:15
am
STRUCTURAL BASIS FOR NUCLEOTIDE EXCHANGE AND
POWER STROKE GENERATION BY THE KINESINMOLECULAR
MOTOR. Zhiguo Shang, Roseanne Csencsits, Chen Xu,
Jared C. Cochran,
Charles Vaughn Sindelar
2239-P
lat
11:30
am
BIMODALITY IN A SYSTEMOF ACTIVE AND PASSIVE KINESIN-1
MOTORS.
Lara Scharrel
, Rui Ma, Frank Jülicher, Stefan Diez
2240-P
lat
11:45
am
A COMPARATIVE STUDY OF THE MAJOR BIOCHEMICAL
STATES OF KINESIN-MT COMPLEX USING COMPUTATIONAL
TECHNIQUES AND ALL-ATOM STRUCTURAL MODELS.
Srirupa Chakraborty
, Wenjun Zheng
2241-P
lat
12:00
pm
SELF-REGULATION OF CYTOPLASMIC DYNEIN THROUGH
ITS UNCONVENTIONAL FORCE RESPONSE.
Takayuki Torisawa
,
Ken’ya Furuta, Akane Furuta, Muneyoshi Ichikawa, Kei Saito, Kazuhiro
Oiwa, Hiroaki Kojima, Yoko Yano Toyoshima
2242-P
lat
12:15
pm
DYNEIN’S C-TERMINAL DOMAIN PLAYS A NOVEL ROLE IN
REGULATING FORCE GENERATION. Peter Höök, Matthew P. Nicholas,
Sibylle Brenner, Caitlin Lazar, Sarah J. Weil, Richard B. Vallee,
Arne Gennerich
2243-P
lat
12:30
pm
REGULATORY PROTEINS ENABLE THE KINESIN KIP2 TO
OVERPOWER CYTOPLASMIC DYNEIN.
Anthony J. Roberts
,
Brian S. Goodman, Samara L. Reck-Peterson
11:00
am
–12:30
pm
, R
oom
123
Exhibitor Presentation
Nanion Technologies
SURFE2R
—
Catch the Wave for Transporters.
Precise Measurements of Membrane Transporter Protein Activity
Ion transporters and pumps play an important role within general
metabolism and information processing of organisms. Dysfunction and
regulation of transporter proteins are related to diseases like obesity, diabe-
tes, and hypertension, and CNS disorders such as epilepsy and depression.
Hence, ion transporters have become potential targets within the drug
development treating disease-related abnormalities. At present, labeling
technologies and conventional patch clamp are commonly used for ion
transporter screening. However, radioactive and fluorescence-based assays
have limited sensitivity, and because of the limited molecule turnover per
seconds of transporters and pumps compared to ion channels, the direct
electrophysiological measurement of protein transporters and pumps ac-
