151
Biophysical Society 58
th
Annual Meeting, San Francisco, California
T
U
E
S
D
A
Y
2830-P
os
B
oard
#B522
BIOPHYSICAL PROPERTIES OF CX40 MUTANTS LINKED TO
ATRIAL FIBRILLATION.
Virgis Valiunas
, Ana Santa Cruz, Laima
Valiuniene, Gulistan Mese, Thomas W. White, Peter R. Brink
2831-P
os
B
oard
#B523
international
travel
awardee
THE MITOCHONDRIAL PERMEABILITY TRANSITION IN
SACCHAROMYCES CEREVISIAE IS CONTROLLED BY HEXOSE
PHOSPHATES FROM THE GLYCOLYTIC PATHWAY.
Monica Rosas-Lemus
, Natalia Chiquete-Felix, Salvador Uribe-Carvajal
2832-P
os
B
oard
#B524
ANO1 - A CANDIDATE FOR ANGIOTENSIN-II-ACTIVATED
CALCIUM DEPENDENT CHLORIDE CHANNEL IN HUMAN
ATRIAL FIBROBLASTS. Antoun El Chemaly, Caroline Norez,
Christophe Magaud, Aurelien Chatelier,
Patrick Bois
2833-P
os
B
oard
#B525
EMERGING ELECTROPHYSIOLOGY OF FACULTATIVE
BACTERIAL PATHOGENS.
Ian Rowe
, Vladislav Belyy, Andriy Anishkin,
Herman Sintim, Anwar Huq, Sergei Sukharev
2834-P
os
B
oard
#B526
THE COUPLING OF TENSION AND CROWDING SENSING IN
THE BACTERIAL CHANNEL MSCS. Andriy Anishkin, Ian Rowe,
Sergei Sukharev
Cardiac Muscle II
(Boards #B527–#B558)
2835-P
os
B
oard
#B527
THERMAL ACTIVATION OF CARDIAC THIN FILAMENTS
INDUCES CONTRACTION WITHOUT INTRACELLULAR CA
2+
CHANGES: STUDIES WITH CARDIOMYOCYTES AND AN
IN
VITRO
MOTILITY ASSAY.
Kotaro Oyama
, Shuya Ishii, Tomomi Arai,
Seine A. Shintani, Hideki Itoh, Norio Fukuda, Madoka Suzuki,
Shin’ichi Ishiwata
2836-P
os
B
oard
#B528
FASTER CROSS-BRIDGE RELAXATION RATES CORRELATE
WITH INCREASED TENSION COST IN HCM WITH THE R403Q
MYH7
MUTATION. Rosalie Witjas-Paalberends, Claudia Ferrara,
Beatrice Scellini, Judith Montag, Ger Stienen, Theresia Kraft,
Michelle Michels, Carolyn Ho, Corrado Poggesi,
Jolanda van der Velden
2837-P
os
B
oard
#B529
THE R403Q MUTATION ALTERS ISOMETRIC AND ENERGETIC
PROPERTIES IN 2 MONTH MICE.
Camille Birch
, John Konhilas
2838-P
os
B
oard
#B530
THE HCM MUTATION R453C IN THE HUMAN BETA MYOSIN
MOTOR DOMAIN ALTERS THE ATP-BINDING AND
HYDROLYSIS STEPS. Marieke Bloemink, John Deacon,
Stephen Langer, Carlos Vera, Ariana Combs, Leslie Leinwand,
Michael A. Geeves
2839-P
os
B
oard
#B531
SPECTROSCOPIC SYSTEM FOR CHARACTERIZATION OF
HUMAN
β
-CARDIAC MYOSIN.
Anja M. Swenson
,
Donald A. Winkelmann, Christopher M. Yengo
2840-P
os
B
oard
#B532
DIFFERENCES IN ACTIVATION AND RELAXATION KINETICS
OF HUMAN FETAL SKELETAL AND CARDIAC MYOFIBRILS.
Alice Ward Racca
, Anita E. Beck, Michael J. Bamshad,
Michael Regnier
2841-P
os
B
oard
#B533
IMPROVED LOADED IN VITRO MOTILITY ASSAY AND
ACTIN FILAMENT TRACKING SOFTWARE DELINEATES THE
EFFECT OF HYPERTROPHIC AND DILATED CARDIOMYOPATHY
MUTATIONS ON THE POWER OUTPUT OF CARDIAC
MYOSIN.
Tural Aksel
, Masataka Kawana, Arjun Adhikari,
Shirley Sutton, Kathleen Ruppel, James Spudich
2842-P
os
B
oard
#B534
MODULATION OF THE CARDIAC SARCOMERE BY A SMALL
MOLECULE AGENT MYK0000461: A POTENTIAL THERAPEUTIC
FOR THE TREATMENT OF GENETIC HYPERTROPHIC
CARDIOMYOPATHIES.
Hector M. Rodriguez
, Stephanie Whitman-Cox,
Raja Kawas, Yonghong Song, Arvinder Sran, Johan Oslob
2843-P
os
B
oard
#B535
BIOPHYSICAL ANALYSIS OF THE PUTATIVE HEART FAILURE
DRUG OMECAMTIV MECARBIL.
Joseph M. Muretta
,
Ewa Prochniewicz, David D. Thomas
2844-P
os
B
oard
#B536
IMPACT OF REGULATORY LIGHT CHAIN PHOSPHORYLATION
ON THE STIFFNESS OF
α
AND
β
MYOSIN. Gerrie P. Farman,
Jeffery R. Moore
2845-P
os
B
oard
#B537
THE EFFECT OF MYOSIN REGULATORY LIGHT CHAIN
PHOSPHORYLATION ON N47K MUTANT MYOSINMECHANICS.
Anastasia Karabina
, Priya Muthu, Katarzyna Kazmierczak,
Danuta Szczesna-Cordary, Jeffrey Moore
2846-P
os
B
oard
#B538
VENTRICULAR MYOSINMODIFIES IN VITRO STEP-SIZEWHEN
PHOSPHORYLATED.
YihuaWang
, Katalin Ajtai, Thomas P. Burghardt
2847-P
os
B
oard
#B539
A13T MUTATION IN THE REGULATORY LIGHT CHAIN
ASSOCIATED WITH CARDIAC HYPERTROPHY IMPOSES
DIFFERENCES IN KINETICS OF HEALTHY AND DISEASED
VENTRICLES.
Janhavi Nagwekar
, Divya Duggal, Krishna Midde,
Priya Muthu, W Huang, Rafal Fudala, Ignacy Gryczynski,
Zygmunt Gryczynski, Danuta Szczesna-Cordary, Julian Borejdo
2848-P
os
B
oard
#B540
THE K104E MUTATION OF THE MYOSIN REGULATORY
LIGHT CHAIN ALTERS KINETICS AND DISTRIBUTION OF
ORIENTATIONS OF CROSS-BRIDGES IN TRANSGENIC
CARDIAC MYOFIBRILS.
Divya Duggal
, Janhavi Nagwekar, Ryan Rich,
W Huang, Krishna Midde, Rafal Fudala, Ignacy Gryczynski,
D Szczesna-Cordary, Julian Borejdo
2849-P
os
B
oard
#B541
MEASURING WORK LOOPS IN INTACT ISOLATED CARDIAC
MYOCYTES BY CONTROLLING PRE- AND AFTERLOAD USING
A NEW GENERATION FORCE TRANSDUCER.
Michiel Helmes
,
Ernst J. Breel, Davide Iannuzzi, Jolanda van der Velden
2850-P
os
B
oard
#B542
TEMPERATURE AND TRANSMURAL REGION INFLUENCE
FUNCTIONAL MEASUREMENTS IN UNLOADED LEFT
VENTRICULAR CARDIOMYOCYTES.
Charles S. Chung
,
Kenneth S. Campbell
2851-P
os
B
oard
#B543
A NOVEL METHOD FOR ISOLATING AND CULTURING
HUMAN CARDIOMYOCYTES FROMCRYOPRESERVED
TISSUES.
Carmine Gentile
, Bernard Kuehn, Michael J. Davies,
Cristobal G. dos Remedios
