194
Biophysical Society 58
th
Annual Meeting, San Francisco, California
3750-P
os
B
oard
#B478
PROBING MECHANISMS THROUGH WHICH DRUGS AFFECT
VOLTAGE-SENSITIVE GATING.
Zachary Beller
, Mark Zaydman,
Jianmin Cui
3751-P
os
B
oard
#B479
SINGLE MOLECULE FLUORESCENCE OF AN S4-BASED
VOLTAGE SENSOR.
Jeremy S. Treger
, Michael F. Priest,
Tomoya Kubota, Ludivine Frezza, Francisco Bezanilla
3752-P
os
B
oard
#B480
EFFECTS OF DECREASED HYDROPHOBICITY ABOVE R1
IN S4-BASED VOLTAGE SENSORS.
João L. Carvalho-de-Souza
,
Jerome J. Lacroix, Francisco Bezanilla
3753-P
os
B
oard
#B481
GENETICALLY-ENCODED FLUORESCENT VOLTAGE SENSORS
CAPABLE OF RESOLVING A 6MV DEPOLARIZATION.
Arong Jung
3754-P
os
B
oard
#B482
THE EFFECT OF INTERHELICAL LOOP LENGTH AND
COMPOSITION ON THE ELECTROSTATIC INTERACTIONS
OF THE VOLTAGE SENSOR DOMAIN OF JSHAK1.
Nazlee Sharmin, Matthias Ostermaier,
Warren J. Gallin
3755-P
os
B
oard
#B483
DIRECT EVIDENCE OF CONFORMATIONAL CHANGES
ASSOCIATED WITH VOLTAGE-GATING IN A VOLTAGE
SENSOR PROTEIN BY TIME-RESOLVED X-RAY/NEUTRON
INTERFEROMETRY.
J. K. Blasie
, A Tronin, J W. Strzalka, I Kuzmenko,
D Worcester, V Lauter, J A. Freites, D J. Tobias
3756-P
os
B
oard
#B484
NETWORKS OF COEVOLVING RESIDUES IN VOLTAGE
SENSOR DOMAINS.
Vincenzo Carnevale
, Eugene Palovcak,
Lucie Delemotte, Michael Klein
3757-P
os
B
oard
#B485
A STRUCTURE BASED COURSE-GRAINING PHYSICAL
MODELING OF THE VOLTAGE ACTIVATED KV1.2 CHANNEL -
SIMULATING AND ANALYZING THE FAST GATING
CURRENT.
Ilsoo Kim
, Arieh Warshel
3758-P
os
B
oard
#B486
ROLE OF CHARGED RESIDUES IN THE REGULATION OF
VOLTAGE SENSOR MOVEMENT IN HERG K
+
CHANNELS.
Yue Wu
, Ying Dou, David Fedida
3759-P
os
B
oard
#B487
THE N-TERMINUS OF AUXILIARY BETA SUBUNIT IS
INVOLVED IN THE MODULATION OF VOLTAGE SENSOR
BK PORE-FORMING ALPHA SUBUNIT.
Karen Castillo
3760-P
os
B
oard
#B488
WHOLE-CELL GATING-CHARGE MEASUREMENTS FOR
ANALYSIS OF ALLOSTERIC DOMAIN COUPLING IN HSLO1
BK CHANNELS.
Guido Gessner
, Katharina Held, Toshinori Hoshi,
Stefan H. Heinemann
3761-P
os
B
oard
#B489
PROBING THE VOLTAGE GATED PROTON CHANNEL HV1
WITH FRET.
Victor De la Rosa
, Gisela E. Rangel-Yescas,
Ernesto Ladron-de-Guevara, Leon D. Islas
3762-P
os
B
oard
#B490
THE ACTIVATION KINETICS OF THE VOLTAGE-GATED
PROTON CHANNEL IS DRASTICALLY ACCELERATED BY
UNSATURATED FATTY ACIDS.
Akira Kawanabe
, Yasushi Okamura
3763-P
os
B
oard
#B491
ELECTROSTATIC INTERACTIONS IN THE CLOSED AND OPEN
STATES OF VOLTAGE-GATED PROTON CHANNELS.
Feng Qiu
,
Adam Chamberlin, Sergei Noskov, H. Peter Larsson
3764-P
os
B
oard
#B492
ON THE LOCATION OF BINDING SITES OF
2-GUANIDINOBENZIMIDAZOLE IN THE VOLTAGE-GATED
PROTON CHANNEL.
Adam C. Chamberlin
, Feng Qui, Sergei Noskov,
Peter Larsson
3765-P
os
B
oard
#B493
INHIBITION OF VOLTAGE-GATED HV1 CHANNEL BY
GUANIDINE DERIVATIVES.
Liang Hong
, Iris Kim, Francesco Tombola
3766-P
os
B
oard
#B494
EXPLORING CONFORMATIONAL REARRANGEMENTS
IN A NOVEL VOLTAGE-SENSING PROTEIN.
Ferenc Papp
,
Erika Babikow, Jaime Smith, Tsg-Hui Chang, Kenton J. Swartz
3767-P
os
B
oard
#B495
THE RESTING STATE OF HUMAN PROTON CHANNEL FROM
FUNCTIONAL AND STRUCTURAL DETERMINATIONS.
Qufei Li
, Sherry Wanderling, Eduardo Perozo
3768-P
os
B
oard
#B496
ELECTROMECHANICAL COUPLING IN GATING OF THE
HV1 VOLTAGE SENSOR IS REVEALED BY RESTING-STATE
CURRENTS IN AN S4 ARG TO HIS MUTATION (R205H).
I. Scott Ramsey
, Aaron L. Randolph
3769-P
os
B
oard
#B497
LONG ALPHA-HELICES PROJECTING FROM THE MEMBRANE
AS THE DIMER INTERFACE IN THE VOLTAGE-GATED H
+
CHANNEL.
Yuichiro Fujiwara
, Tatsuki Kurokawa, Yasushi Okamura
3770-P
os
B
oard
#B498
PH SENSITIVITY OF VOLTAGE SENSING DOMAIN
RELAXATION.
Carlos A. Villalba-Galea
3771-P
os
B
oard
#B499
GATING-COUPLED CLUSTERING-DISPERSION DYNAMICS OF
THE KCSA POTASSIUM CHANNEL IN A LIPID MEMBRANE.
Ayumi Sumino
, Daisuke Yamamoto, Masayuki Iwamoto, Takehisa Dewa,
Shigetoshi Oiki
3772-P
os
B
oard
#B500
TOWARDS THE INCORPORATION OF FUNCTIONAL ION
CHANNEL PROTEINS IN TETHERED MEMBRANES.
David P. Hoogerheide
, Amit Vaish, Tatiana Rostovtseva, Adam Kuszak,
Sergey Bezrukov, Susan Krueger, Hirsh Nanda
3773-P
os
B
oard
#B501
A NOVEL MECHANISM OF VOLTAGE SENSING AND GATING
IN K2P POTASSIUM CHANNELS.
Marcus Schewe
, Markus Rapedius,
Ehsan Nematian-Ardestani, Thomas Linke, Klaus Benndorf,
Stephen J. Tucker, Thomas Baukrowitz
3774-P
os
B
oard
#B502
SHIFTING THE GATING EQUILIBRIUM OF A POTASSIUM
CHANNEL VIA HYDROPHOBIC MISMATCH.
Dylan O. Burdette
,
Adrian Gross
3775-P
os
B
oard
#B503
CORRELATED SINGLE-MOLECULE SPECTROSCOPY AND
PATCH-CLAMP STUDIES OF VOLTAGE GATED ION CHANNEL
ACTIVATION DYNAMICS IN LIVING CELLS. Dibyendu Sasmal,
H. Peter Lu
