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0 10 20 30 40 50 60 70 80 90 100

0

15

30

45

60

75

90

Dose

Δ

Veff

max 60% (80% in Trial 1)

Liver Veff

Prescription dose

<25

6 x 9.0 Gy

25-30

6 x 7.5 Gy

30-40

6 x 6.5 Gy

40-50

6 x 5.5 Gy

50-60

6 x 5.0 Gy

>60

Not suitable

NTCP based dose prescription

Risk adapted

Veff:

Effective irradiated liver volume (dose-weighted irradiated volume)

Laura Dawson, PMH Toronto

Liver minus CTV