1138-1139 / 1578
Phase III TOAD trial
: Effects of androgen-deprivation therapy on health-related quality of life
in asymptomatic patients who have either a rising PSA after curative radiotherapy or
prostatectomy but no overt disease, or who have non-curable disease at the outset
•
Sexual activity lower in the
immediate therapy group
than in the delayed
group at 6 and 12 months, with the differences exceeding the clinically
significant threshold of 10 points until beyond 2 years
•
Immediate therapy group
had more hormone-treatment-related symptoms at
6 and 12 months in the immediate group, but differences were below the
threshold of clinical significance
•
Immediate therapy group had clinically significantly higher incidence of hot
flushes over the 5-year period, as were nipple or breast symptoms
Duchesne GM, Lancet Oncol 2017
ADT and health-related quality of life