1214 / 1578
Radiotherapy: WBRT- with integrated boost
plus hippocampal-sparing
Study
design
Endpoint
Planning comparison
Dose
PTV
wb
/dose
PTV m(Gy)
Cases
(lesions)
Main findings
Hsu
2010
Feasibility WBRT+SIB(VMAT) vs SRS
32.25 (63-70) 10(1-3)
Adequate WBRT and
SRT dose distribution
Rodrigues
2011
Phase 1 WBRT+SIB
30 (35-60)
48(1-3)
60 Gy /10 f. to 1-3 mets
synchron.with 30 Gy
WBRT feasible
Nichol
2016
Phase 2 WBRT+Volumetric
Radiosurgery
20 (47.5)
60 (223)
For non deep BM
47.5 Gy /5f is feasible
Ferro
2017
Phase 1 WBRT+SIB(IMRT)
30 (35-50)
30(1-5)
50 Gy /10f to 1-5 meta
feasible
•
Treatment planning is possible
•
Long term results of neurocognitive decline are not available