1216 / 1578
B. Müller, M. Bamberg, P. Krauseneck, Maligne Gehirntumoren, 1995
Blood brain barrier
Zytostatikum
Liquorpenetration
Nitrosoureas
(ACNU,BCNU; CCNU, Fotemustine)
++
Procarbacin
++
Thiotepa
+
Dacarbacin
Temozolomide
(+)
++
Cyclophosphamid, Ifosfamid
+/-
Cytosinarabinosid
++
Methotrexat
-/+
5-Fluorouracil
(++)
Anthracyclins
Liposomal doxorubicine
-
++
VM26
-/+
Etoposid
-/+
Vincaalkaloids, Taxanes
-
Topotecan
++
Cisplatin, Carboplatin
-
Cytokines
-
++ : Liquorconzentration 20-30% of the Serumconzentration
+ : Liquorconzentration 10% of the Serumconzentration
– : Liquorconzentration <5% of the Serumconzentration
There is a limited effect of Chemotherapy in brain metastases