Table of Contents Table of Contents
Previous Page  191 / 1578 Next Page
Information
Show Menu
Previous Page 191 / 1578 Next Page
Page Background

MCA 129 fibrosarcoma and B16F1 melanoma grown in apoptosis resistant

acid sphingomyelinase (asmase)-deficient or Bax-deficient mice

Reduced tumor endothelial apoptosis in asmase -/-

mice. Tumors grew 2-4 x faster than in the wild-type.

Tumors with apoptosis-resistent vascular endothelium

were resistant to radiation

Science 300: 1155; 2003

Endothelial response to high RT doses