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MCA 129 fibrosarcoma and B16F1 melanoma grown in apoptosis resistant

acid sphingomyelinase (asmase)-deficient or Bax-deficient mice

Reduced tumor endothelial apoptosis in asmase -/-

mice. Tumors grew 2-4 x faster than in the wild-type.

Tumors with apoptosis-resistent vascular endothelium

Were resistant to radiation

Endothelial apoptosis was observed with doses >8 Gy

in wild-type endothelium.

Science 300: 1155; 2003

Endothelial response to high RT doses