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MCA 129 fibrosarcoma and B16F1 melanoma grown in apoptosis resistant
acid sphingomyelinase (asmase)-deficient or Bax-deficient mice
Reduced tumor endothelial apoptosis in asmase -/-
mice. Tumors grew 2-4 x faster than in the wild-type.
Tumors with apoptosis-resistent vascular endothelium
Were resistant to radiation
Endothelial apoptosis was observed with doses >8 Gy
in wild-type endothelium.
Science 300: 1155; 2003
Endothelial response to high RT doses