236 / 1578
/
Ø
Adaptation of dose profile
within
the PTV
Dose escalation WITHIN the PTV
Central location
Prostate
Spine
Bone
Ø
Fracture
Urethra
Ø
Scricture
Bronchi
Ø
Stenosis
07.09.17
Matthias Guckenberger - ESTRO SBRT Course 2017
29
/
C O N C L U S I O N S
Ø
Dose explains high rates of local tumor control
Ø
LQ model describes reasonably well what we observe
in clinical practice
Ø
Dose-response not different between primary NSCLC
and pulmonary metastases
Ø
PTV encompassing dose >100Gy BED achieves
>90% TCP
Ø
Total dose adapted to competing risk of death / distant
progression
Ø
Fractionation adapted to risk of OAR toxicity
07.09.17
Matthias Guckenberger - ESTRO SBRT Course 2017
30