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Acquisition of resistance
Ø
Development of acquired resistance unlikely a systemically
parallel process but a cascade of sequential events
Targeted
Tx
„Oligo“
Resistance
„Systemic“
Resistance
ESTRO SBRT COURSE 2017 - Matthias Guckenberger
19
07.09.17
/
Acquisition of resistance:
A potential role for targeted radiotherapy
Ø
Local eradication of the oligo-resistant tumor site(s) to keep
the patient in a sensitive state
Targeted
Tx
Restore
Sensitivity
„Oligo“
Resistance
ESTRO SBRT COURSE 2017 - Matthias Guckenberger
20
07.09.17