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How large should the margin be?

What is the incentive?

99% of the target volume receives 95% of the prescribed dose or more

(coverage probability) -

Stroom et al.

90% of patients in the population receives a minimum cumulative CTV

dose of at least 95% of the prescribed dose -

van Herk et al.

Not all patients will be treated to 100%

of the prescription dose in all fractions

M = 2.5

S

+ 0.7

s