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Uncertainty in Motion
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A single pre-treatment 4DCT is often not representative for the magnitude of
motion during the treatment delivery
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Substantial tumor motion during breath-holding
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Jiajia Ge at al., Int J Radiation Oncol Biol Phys, Vol. 85, No. 4, pp. 999e1005, 2013
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Lens E, van der Horst A, Versteijne E, Bel A, van Tienhoven G. Considerable pancreatic tumor motion during
breath-holding. Acta Oncol. 2016 Nov;55(11):1360-1368.
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Lens E, van der Horst A, Kroon PS, van Hooft JE, Dávila Fajardo R, Fockens P, van Tienhoven G, Bel A.
Differences in respiratory-induced pancreatic tumor motion between 4D treatment planning CT and daily
cone beam CT, measured using intratumoral fiducials. Acta Oncol. 2014 Sep;53(9):1257-64.