ESTRO 36 Abstract Book

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S162 ESTRO 36
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Material and Methods
This study was conducted within the Dutch UMBRELLA
cohort (i.e. prospective observational cohort including
breast cancer patients indicated to receive adjuvant
radiotherapy at the department of Radiation Oncology at
the University Medical Centre Utrecht). All participants
consented to collection of clinical data and patient
reported outcomes (PROMs). Arm function and Quality of
Life (QoL) were measured by EORTC QLQ-C30 and BR23.
We first compared differences in mean PROM scores
between patients who underwent ALND and those who did
not by two sample t-test. In a second step, we estimated
the effect of extent of axillary radiotherapy on PROM
scores in patients stratified on ALND, and used analyses of
variance (ANOVA) to test for differences. Finally, we
compared patients who underwent ALND and local RT with
non-ALND patients treated with axillary RT to estimate the
differences between axillary RT and ALND.
Results
Between October 2013 and December 2015, 521 patients
were enrolled. In total 75% (n=390) of the patients were
treated with local radiotherapy on the breast/chest wall
(local RT), 10% (n=53) received additional axillary
radiotherapy on level I and II (local RT + level I-II) and 15%
(n=78) of the patients received local radiotherapy with
axillary irradiation including levels III and IV (local RT +
level I-IV) (Table 1). ALND (n=84) was performed in 10%
(n=40) of the patients in the local RT group and in 56%
(n=44) of the locoregional RT group (Table 1). Patients in
the ALND group reported significantly lower arm function
compared to the non-ALND group (Figure 1A-B). For
patients who underwent ALND and local RT, arm symptoms
were significant worse at baseline and 3 months compared
to non-ALND patients who received local RT and axillary
(level I-II or level I-IV) irradiation (MD -15.2, p=0.00 and -
13.4, p=0.00) (Figure 1C). Overall QoL scores were similar.
Conclusion
Arm function in patients treated with ALND was worse
compared to patients without ALND. Patients reported
significant more arm symptomatology after ALND followed
by local RT compared to non-ALND patients treated with
local RT and axillary irradiation in the first 3 months after
start of RT. Updated results on PROMs with increased
patient numbers, longer follow-up and multivariable
analyses will be available at the 36th ESTRO conference.
SP-0314 Partial breast radiotherapy after breast
conservation: 5 year outcomes from the IMPORT LOW
(CRUK/06/003) phase III trial
C. Coles1, C. Griffin2, A. Kirby3, R. Agrawal4, A. Alhasso5,
I. Bhattacharya 2, A.M. Brunt6, L. Ciurlionis7, H. Chan8, E.
Donovan3, M. Emson2, A. Harnett 9, J. Haviland2, P.
Hopwood 2, M. Jefford10, R. Kaggwa2, E. Sawyer11, I.
Sybdikus12 , Y. Tsang13, D. Wheatley14, M. Wilcox15, J.
Yarnold16, J. Bliss2
1Cambridge Cancer Centre, University of Cambridge,
Cambridge, United Kingdom
2Clinical Trials and Statistics Unit, Institute of Cancer
Research, London, United Kingdom
3Royal Marsden NHS Foundation Trust, Department of
Radiotherapy, London, United Kingdom
4Shrewsbury and Telford Hospitals NHS Trust, Oncology
Department, Shrewsbury, United Kingdom