ESTRO 36 Abstract Book

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S628 ESTRO 36
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Figure 2. Variation of red blood cell concentration in
irradiated skin of breast cancer patients
Conclusion
The results showed that radiation-induced microvascular
changes in the skin can be objectively measured using
novel camera-based techniques before visual changes in
the skin are apparent. Also, the proposed methods may be
valuable in the comparison of skin reactions between
different radiation treatments.
EP-1155 Outcomes of breast cancer patients older
than 80 years treated with adjuvant radiotherapy
R. Barrientos1, M. Frelinghuysen2, M. Burotto3
1 Instituto de Radiomedicina IRAM, Radiation Oncology,
Concepcion, Chile
2 Hospital Clinico Regional de Concepcion, Radiation
Oncology, Concepcion, Chile
3 Clinica Alemana de Santiago, Medical Oncology,
Santiago de Chile, Chile
Purpose or Objective
The main purpose was to estimate surviva l of patients
older than 80 years, diagnosed by Stage I-III breast cancer
that were treated by surgery and adjuvant radiotherapy
with curative intent. Breast cancer specific survival
different clinical and pathologic factors that influence
survival were estimated.
Material and Methods
We analyzed 85 breast cancer patients older than 80 years
old that received surgery and adjuvant radiotherapy with
curative intent. Overall survival was defined as the time
from the date histopathological diagnosis until the last
date of follow-up (official death certificate). Survival was
performed by Kaplan Meier method. A log rank test was
used to compare survival of different clinical and
pathological factors. Signficance level was determined by
(p-value <0.05).
Results
The median age at the time of diagnosis was 82.7 (range
77 to 88). The median follow up was 42 months. Overall
survival was 70% at 5 years. Breast cancer specific survival
(BCSS) was 94% a 5 years. Four patients (4.2%) died of
cardiovascular disease. Fifty five patients (65%) received
partial mastectomy, while 30 patients (35%) received total
mastectomy (MT). Fifty four patients (63%) received whole
breast or chest wall irradiation, while 31 patients (37%)
received locorregional irradiation. Five patients presented
cutaneous toxicity grade ≥ the univariate analysis
Clinical preoperative nodes, clinical tumor, locorregional
irradiation and pathologic tumor stage were significant for
overall survival . No other examined factor was
significant.
Conclusion
Patients older than 80 treated by Stage I-III breast cancer
have long survival after treatment. OS and BCSS is high at
five years. Patients with locally advanced preoperatory
disease, pathologic tumor size and locorregional
irradiation contributed negatively to survival.
EP-1156 A clinical trial on hypofractionated whole-
breast irradiation after breast-conserving surgery
M. Nozaki1, Y. Kagami2, T. Shibata3, K. Nakamura4, Y.
Ito5, Y. Nishimura6, Y. Kawaguchi7, Y. Saito8, Y. Nagata9,
Y. Matsumoto 10, T. Akimoto11, T. Nishimura12, T. Uno13 , K.
Tsujino14, M. Kataoka15, T. Kodaira 16, K. Shiraishi17, K.
Inoue18, F. Isohashi19, M. Hiraoka20, K. Karasawa21, S.
Izumi22, H. Sakurai23
1Dokkyo Medical University Koshigaya Hospital,
Radiology, Koshigaya, Japan
2Showa University School of Medicine, Radiation
Oncology, Shinagawa, Japan
3National Cancer Center, Statistical Section- The Japan
Clinical Oncology Group Data Center, Chuo, Japan