10 / 97
made for every batch and that relative difference (daily average vs. overall aver-
age) is low this is seen as being acceptable.
For Carnitine the RSD% will be set to 5% for carnitine.
Trueness:
The methods trueness has been evaluated by analysing reference material.
Reference materials:
Reference materials with values on carnitine exist or are at the moment under
testing for certification.
We have analysed the certified reference material SRM 1849A (Infant/adult nutri-
tional formula), SRM 1546 (Meat Homogenate) and SRM 1845A (Whole Egg
powder, under certification).
Sample: NIST SRM 1849A
Matrix: Infant/adult nutritional formula.
Species Result (m)
n Reference value (CRM) k Comment
carnitine 140 ± 2 mg/kg 4 136 ± 14 mg/kg
2 free
The certified values have been evaluated according to ERM application Note 1.
1
Example of the calculation:
The certified content of free carnitine is (136 ± 14) mg/kg,
k
= 2,00.
The SRM 1849a was analysed 4 times. (140 ± 2) mg/kg.
If
Δ
m
≤
U
Δ
then no significant difference between the measurement result and the
certified value has been demonstrated.
1
http://irmm.jrc.ec.europa.eu/html/reference_materials_catalogue/user_support/index.htm.Carn-06 - Validation Report
FOR ERP USE ONLY
DO NOT DISTRIBUTE