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Limits of Feedback Control

Adaptive

attempts to correct the mean (accuracy), and

address the variation (precision) with optimal patient-

specific margins.

Gating

and “Tracking” try to control the beam and target

positioning in real-time, with minimal PTV margins.

What happens when knowledge is out of date?

What happens when we can’t measure fast enough?

Delayed evaluation

inference from sources outside the scope of the intervention?

Uncertainty!

- efforts to control are wasted