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Value of FDG-PET for the GTV-T definition
Allal et al.
IJROBP
2004;59:1295-300.
Koyasu et al.
AJR Am J Roentgenol
2014;202:851-8
.
Jeraj et al.
J Nucl Med
2015;56:1752-65.
Gregoire et al.
JCO
2015;33:3277-84.
• Pretreatment FDG-PET (SUV, uptake pattern, …) correlates with:
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Local control
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Disease-specific survival
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Disease-free survival
• GTV delineation:
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Manual: boundary definition of the GTV combined with CT and/or MR
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Threshold-based: subvolume boost
• Smaller FDG-PET-based GTV-T
•
Smaller CTV-T and PTV-T
•
Better sparing of OARs
•
Dose prescription:
•
Dose painting