879 / 1481
Radical prostatectomy
Assess need: Is immediate post-operative
RT required?
Uncertain
Yes
Hormone duration
RANDOMISATION
RT +
no HT
RT +
6mo HT
RT +
2yr HT
Monitor on
trial
RT +
no HT
RT +
6mo HT
RT +
2yr HT
Salvage
RT policy
Hormone duration
RANDOMISATION
RT timing
RANDOMISATION
Monitor off
trial
Rise in PSA
Immediate
RT
Salvage
RT policy
Immediate
RT
No
RADICALS
- overall design
On trial
Off trial
Treatment
Key
No rise in
PSA
To address 2 important post-op
XRT issues
•Need for and timing of post-op XRT
immediate
(adjuvant)
salvage
(deferred / early salvage)
•Use and duration of hormones & post-op XRT
none
(0 months)
short
(6 months)
long
(24 months)
MRC & NCIC Collaborative: RADICALS Trial (CI: C Parker)