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Biophysics in the Understanding, Diagnosis, and Treatment of Infectious Diseases Program
4
Session II
Chair: Edward Egelman, University of Virginia, USA
15:00 – 15:20
Stefan Barth, University of Cape Town, South Africa
Use of Supercomputational Simulation of Dynamic Protein Interaction to
Generate Knowledge-driven Targeted Fusion Proteins for Treatment of
Infectious Diseases
15:20 – 15:40
Constantinos Kurt Wibmer, National Institute for Communicable Diseases,
South Africa*
Structural Characterisation of an HIV-1 Broadly Neutralising Antibody
Epitope in the gp120-gp41 Interface
15:40 – 16:20
Stefan Raunser, Max Planck Institute of Molecular Physiology, Germany
How to Kill a Mocking Bug—Structural Insights into Tc Toxin Complex Action
16:20 – 16:40
Brian Baker, University of Notre Dame, USA*
High Resolution, High Throughput Structural Modeling of T Cell Receptor
Specificity and Cross-Reactivity: Implications for Immunotherapy
16:40 – 17:10
Coffee Break
17:30 – 19:30
Poster Session I
Old Wine Cellar
Tuesday, November 17, 2015
8:00 – 17:00
Registration/Information
Auditorium Foyer
Session III
Chair: James Sacchettini, Texas A&M University, USA
8:30 – 9:10
Tom Blundell, University of Cambridge, United Kingdom
Biophysical Methods and Fragment-based Drug Discovery for Infectious
Disease: Targeting Mycobacterium Tuberculosis and Mycobacterium
Abscessus
9:10 – 9:50
Robin Wood, Desmond Tutu HIV Centre (UCT), South Africa
Novel Approaches to the Aerobiology of Tuberculosis Transmission
9:50 – 10:10
Adam Yadon, Harvard University, and KwaZulu-Natal Research Institute for
Tuberculosis and HIV, USA*
Comprehensive Mutational Analysis of PncA SNPs Conferring in Vitro and in
Vivo Pyrazinamide Resistance in M. Tuberculosis
10:10 – 10:40
Coffee Break
10:40 – 11:20
Valerie Mizrahi, University of Cape Town, South Africa
Identifying Vulnerable Steps in the CoA Biosynthesis Pathway of M. Tuberculosis
11:20 – 12:00
Robert Stroud, University of California San Francisco, USA
Targeting the Membrane Proteome of mTB for Structure based Approaches to
Function
12:00 – 12:20
Eric Galburt, Washington University School of Medicine, USA*
Kinetic Regulation of Open Promoter Complexes by Mycobacterial
Transcription Factors
*Short talks selected from among submitted abstracts