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Chordoma and Chondrosarcoma
03/01/13
CHORDOMA
Presumed to arise from remnants of
primitive notochord, an
embryonic precursor replaced by
mesodermal elements to form
vertebrae and skull base
Typically midline
CHONDROSARCOMA
• Arise from embryonal rests of
cartilaginous matrix that escape
reabsorption during endochondral
ossification
• Off-midline and originate within the
temporal bone and petroclival
fissure