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Chordoma Chondrosarcoma
03/01/13
CHORDOMA - Pathology
Macroscopically:
Chordomas are soft, gelatinous, lobulated neoplasms
Microscopically:
Vacuolated, bubble-containing cytoplasm:
physaliphorous cells
Express S-100, EMA and cytokeratin
Notochordal developmental transcription factor,
BRACHYURY
(when combined
with cytokeratin staining, sensitivity of 98% and specificity of 100% for
chordoma)
Chondroid Chordoma:
Favorable prognosis (UNRESOLVED ISSUE)
About 20% were later found to be chondrosarcomas
Mayo clinicopath study revealed no difference in survival (attributed to
occurrence in younger pts)