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PHYSIOLOGICAL IMAGING
PERFUSION MRI
•
Provides hemodynamic information and estimates the cerebral blood volume that
reflect the underlying microvasculature
•
Exploit signal changes that accompany the passage of a paramagnetic contrast
agent thorugh the cerebrovascular system
•
Useful if patients receive antiangiogenetic cancer therapies to monitor its
efficacy
•
Maps of cerebral blood volume can serve as an additional targets for brain
tumour biopsies
•
May help in differentiating radiation necrosis and recurrent tumour
•
May help differentiating tumor infiltrated edema (high grade gliomas) and
vasogenic edema (in case of metastases)
PITFALL:
NO CORRELATION
WITH TUMOR GRADING
Di Stefano et al. 2014