23 / 1266
IMAGING TUMOR PROLIFERATION
[(18)F]-FLT-PET
fluorothymidine
•
Uptake of FLT correlates with
Thymidine kinase-1 activity
expressed during DNA synthesis
•
High correlation with Ki-67
expression (Yamamoto J Nucl Med
2012)
•
Might be superior to MET for
tumour grading
•
The kinetics of FLT uptake are
closely related to prognosis,
early efficacy of treatment and
to outcome (Wardak Clin Cancer
Research 2011)
•
PITFALLS
:
•
less sensitivity than MET for
low grade gliomas
•
CANNOT PREDICT GRADE
Oligodendroglioma Grade I
Astrocytoma Grade II
Anaplastic
Oligodendroglioma Grade II
GBM Grade IV