510 / 1266
42 year old patient with MGMT methylated GBM, >90% resection, RT-
TMZ. Recurrent, inoperable disease 14 months after completing
adjuvant TMZ; PS=1. I would recommend:
A. TMZ rechallenge, 5/28 day schedule
B. TMZ rechallenge, 21/28 day schedule
C. PCV
D. TMZ + bevacizumab
E. Bevacizumab + irinotecan