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61 year old patient with MGMT unmethylated GBM, >90% resection,
RT-TMZ. Recurrent, inoperable disease 5 months after completing
adjuvant TMZ; PS=1. I would recommend:
A. TMZ rechallenge, 5/28 day schedule
B. PCV
C. TMZ + bevacizumab
D. Bevacizumab + irinotecan
E. Best supportive care