719 / 1266
Biopsy directed therapies
•
Molecularly Determined Treatment of Diffuse
Intrinsic Pontine Gliomas (DIPG).
NCT01182350
–
up-front stereotactic biopsy of classic DIPG used to
stratify patients to different therapies based on the
MGMT (temozolomide) and EGFR (erlotinib)
expression in combination with focal radiation therapy
and bevacizumab
•
BIOMEDE- Biologically-driven phase I/II study in
children and adolescent with DIPG