720 / 1266
BIOMEDE Study
EGFR TKI + RT
(erlot inib)
EGFR +++ ( IHC)
EGFR amplif . (FISH)
No PTEN loss ( IHC)
PDGFR TKI + RT
(dasat inib)
PDGFRA amplif . (FISH)
PDGFRA mut at ed ?
PDGFRA +++ ( IHC) ?
mTOR inhibit or + RT
(everolimus)
No EGFR alt erat ion
No PDGFRA alt erat ion
PI3KCA mut at ions
Diagnosis (clinic+Rx)
St ereot act ic biopsies
Marker screen (FISH/ IHC)
CGHarray/ mut at ion screen