721 / 1266
Three major targets selected
•
EGFR
–
Rarely amp/mut, frequently overexpressed
•
mTOR pathway
–
Activated by genomic alteration in ½ of DIPG
(Taylor et al, Nat Genet in press).
–
PTEN loss in 80% of DIPG.
•
PDGFRA pathway
–
PDGFRAamp/mut in 20% of DIPG