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Medulloblastoma
History of Chemotherapy Clinical Trials:
1970s-1980s:
- Adjuvant chemotherapy
- SIOP I,CCSG 942
1980s-1990s:
- Pre-RT (Sandwich CT)
- SIOP II, SIOP/UKCCSG PNET 3
- Pre vs post RT chemotherapy : HIT 91,CCG 921
- CCG 9862 adjuvant chemotherapy (CVP)
Chemo better for high-risk subgroups
Standard dose RT (35-36 Gy
established)
Intensive sandwich CT better than RT
alone (PNET 3)
Immediate RT better than delayed
Cisplatin,
VCR,CCNU
chemo standard and
reduced dose RT (23.4
Gy) established