815 / 1266
Reduced dose Cranio Spinal Irradiation with CT
PFS
65 “Standard-Risk” patients:
RT doses
Craniospinal: 23.4 Gy
Posterior fossa: 55.2 Gy
Concomitant CT:
weekly Vincristine
Adjuvant CT:
Vincristine
CCNU
Cisplatin
“These overall survival rates compare favorably to those obtained in studies using full-dose radiation
therapy alone”
Packer, J Clin Oncol 1999; 17:2127-36