990 / 1266
LDE225 induced tumor regression is associated with
Gli1 suppression in tumor
Ptch
+/-
p53
-/-
mouse allograft
5mg/kg
10 mg/kg
20 mg/kg
8 10 12 14 16 18 20 22
0
500
1000
1500
2000
2500
3000
Days Post Implantation
Tumor volume (mm
3
)
mean ± SEM
Vehicle
Vehicle 4hr
8hr
16hr
24hr
0
50
100
150
LDE225
Gli1 expression of Vehicle (%)
Vehicle 4hr
8hr
16hr
24hr
0
50
100
150
LDE225
Gli1 expression of Vehicle (%)
Vehicle 4hr
8hr
16hr
24hr
0
50
100
150
LDE225
Gli1 expression of Vehicle (%)
LD
E22