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The 5-Gene Hh Signature
GLI1
SHROOM2
SPHK1
PDLIM3
OTX2
Up-regulated
Down-regulated
Control genes:
HUWE1, YME1L1, SOD1, LARP1
The 5-gene Hh signature can
robustly identify Hh-pathway
activation in FFPE tumor
samples by standard RT-PCR
Hh activation status
determined by the 5-gene Hh
signature is in 100%
agreement with the Hh status
determined by Affymetrix
A robust patient pre-selection
tool for LDE225 treatment
GLI1, glioma-associated oncogene homolog 1; HUWE1, HECT, UBA and WWE domain containing 1; LARP1, la ribonucleoprotein domain family, member
1;OTX2, orthodenticle homeobox 2; SHROOM2, shroom family member 2; SOD1, superoxide dismutase 1, soluble; PDLIM3, PDZ and LIM domain 3; SPHK1,
sphingosine kinase 1; YME1L1, YME1-like 1; ZP2, zone pellucida sperm-binding protein 2.
Amakye D, et al. AACR 2012. Abstract #4818.