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Der er jo imidlertid ikke noget mærkeligt i, at Medicin kan have
en skadelig Virkning paa Organismen: De fleste a f de mest værdi
fulde af vore Lægemidler er mer eller mindre giftige, uden at man
derfor undlader at bruge dem. Man maa blot bruge dem paa rette
Maade. Det samme gælder Paraffinolien; den skal ikke forkætres,
men man skal anvende den under behørig Kontrol.
Man kan maaske til Dels undgaa Ulemperne ved Paraffinolien
ved at give den i en vis Afstand fra Maaltiderne som foreslaaet a f
Jackson.
Man skulde synes, at man ved f. Eks. at give Paraffinolien
paa fastende Hjerte eller sent om Aftenen opnaaede, at den først
naaede Tarmindhold i Tyktarmen, saaledes at Fødens Vitaminind
hold var resorberet inden Paraffinolien kom til.
Det er imidlertid kun Teori, hvis Berettigelse fremtidige Under
søgelser maa afgøre.
Foreløbigt kan vi sammenfatte Resultaterne a f disse Undersøgelser
og sige:
Paraffinolie bør gennem længere Tid kun gives til Patienter, om
hvem man med Sikkerhed ved, at de lever paa en A-Vitamin-rigelig
Kost, og den bør gives i stor Afstand fra Maaltiderne, specielt fra de
Maaltider, der er særlig A-Vitamin-holdige.
Paraffinolie bør ikke gennem længere Tid gives til Patienter med
Resorptionsvanskeligheder.
Summary.
A series of animal experiments are referred, in which it was de
monstrated that oral administration of paraffin oil had a pronoun
ced inhibitory effect upon the utilisation of carotene, and a similar,
if somewhat less pronounced effect upon the utilisation of vitamin
A. It is generally assumed that paraffin oil acts by sweeping part
of the A substances out of the intestine. The difference in effect
upon vitamin A and carotene is presumably due to a difference in
utilisation between these two substances. Animal experiments have
demonstrated that vitamin A is almost completely utilised, whilst
45-65
per cent of the carotene may be found in the stools. Similar
observations have been made in man
(Boiler, Brunner
and
Grant)
If, however, large doses of vitamin A are administered, this sub
stance may be excreted in the stools. Excretion generally begins
12-30
days after administration of vitamin A has been commenced
(Wendt).
Author's own investigations.
As it has been demonstrated that
fairly large amounts of carotene are normally excreted in the stools,
it seemed most suitable to examine the effect of paraffin oil upon
the excretion of vitamin A. Vitamin A has been determined in the
stools photometrically with Car-Price’s reagent in chloroform ex
tract after saponification. In order to obtain identical experimental