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41
conditions, the patients examined were given the same diet (mostly
consisting of milk and oat-meal gruel). Patients who were given a
full diet now and again excreted a substance which gave a blue
colour with the reagent.
To a series of patients vitamin A Was administered as halibut
hver oil (Decamin). In one case
70,000
units were given per
24
hours;
this turned out to be too much, spontaneous excretion occurring;
therefore the remaining patients received only
7000
units per
24
hours. For a period, each patient was given paraffin oil. The stools
were examined before and during administration of paraffin oil,
in the majority of the cases also after.
In the patients who received
7000
units per
24
hours, the follow
ing facts were observed:
1
)
In man paraffin oil may remove some of the vitamin A taken
through the stools.
2
) In no case was more than
25
per cent of the
amount administered demonstrated in the stools. On average
500
units were excreted per
24
hours.
3
) In some few cases slight excre
tion of vitamin A occurred spontaneously.
4
) Vitamin A is most
likely excreted because it is held in solution by the paraffin oil,
not because the paraffin oil accelerates the motion of the intestine.
Control experiments with a purgative did not cause any or only a
very slight excretion of vitamin A.
A patient with sprue was given
7000
units of vitamin per
24
hours.
Every time the patient received vitamin A, there was a consider
able spontaneous excretion in the stools.
Conclusion;
Paraffin oil should be administered for a longer period
of time only to patients about whom it is known that they are receiv
ing a diet rich in vitamin A. It should be given a long time apart
from meals.
Paraffin oil should not be administered for any length of time to
patients suffering from difficulties in absorption.
Litteratur.
Baumann, Steenbock, Beeson and Rupel:
J. Biol. Chem. 1934, 105, 167. •—-
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citeret efter Friderichsen. •—•
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De:
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