ESTRO course on Image Guided Radiotherapy in Clinical Practice 2018

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Uncertainty management: Conventional

IMRT planning with margin

CTV

PTV

Inverse

optimization

Objective functions

Poisson cell kill, EUD,

DVH points, ...

Dose

distribution

90% prob. of

D ≥ 95% D

prescribed

in CTV

M = 2.5

Σ

+0.7

σ

OAR

Witte et al, IJROBP 2007

Bohoslavsky et al IJROBP 2013