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Uncertainty management: Probabilistic
biological IMRT planning without margin
CTV
Inverse
optimization
Objective functions
with simulated errors
TCP
,
NTCP
Dose
distribution
Maximum
TCP
for given
OAR
NTCP
OAR
Σ
,
σ
no PTV margin!
Witte et al, IJROBP 2007
Bohoslavsky et al, IJROBP 2013