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Foecal incontinence
•
Prospective
study
(> 500 pts
), self reported questionnaires
•
Taking into account
severity
and
duration
of symptoms
•
V40>80%
: predictor of Mean Incontinence Score together
with previous bowel symptoms, antiypertensive, surgery
•
Two patterns for occurrence of foecal incontinence after
RT
:
–
1: consequent to
acute effects
and mainly responsible for
peak events
(ca ½ pts recovering from symptoms)
–
2: needs longitudinal analysis- it results form the irradiation of large
fraction of the rectum at intermediate doses (V40), presence of
pretreatment bowel symptoms, previous abdominal-pelvivc surgery for
chronic incontinence
•
Vascular damage, more than damage to sacral nerve ( hypertensive drugs work)
Fiorino
et al
, 2011