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3-years GU (G2-3) toxicities correlated with both high and

“low” dose if empty bladder

(

Harsolia, IJROBP, 2007)

V30Gy < 33.5 cc 2% G3

V30Gy > 33.5 cc 20% G3

V82Gy < 2.5 cc 2% G3

V82Gy > 2.5 cc 12% G3

8 years GU (G1-3) toxicities correlated with “

hottest volume

V78Gy < 2.9 % 25 % 8-years risk

V78Gy > 2.9 % 50 % 8-years risk