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Key is the shape of the dose-response relationship
for radiation-induced carcinogenesis...
High doses don
’
t matter
•
IMRT minimizing high doses helps
•
IMRT
’
s extra lower doses less important
Second Cancers: IMRT vs. 3D-CRT
total dose
total dose
•
IMRT minimizing high doses doesn
’
t help
•
IMRT
’
s extra lower doses are bad
High doses do matter
Cancer Risk
OR